无症状人群颅内脑动脉粥样硬化的危险因素
Risk factors of intracranial cerebral atherosclerosis among asymptomatics.
作者信息
Bae Hee-Joon, Lee Juneyoung, Park Jong-Moo, Kwon Ohyun, Koo Ja-Seong, Kim Byung-Kun, Pandey Dilip K
机构信息
Department of Neurology, Seoul National University Bundang Hospital, Seoul, Korea.
出版信息
Cerebrovasc Dis. 2007;24(4):355-60. doi: 10.1159/000106982. Epub 2007 Aug 9.
BACKGROUND
Little information is available regarding the risk factors for intracranial cerebral atherosclerosis (ICAS), particularly among asymptomatics.
METHODS
Data from a consecutive series of 1,208 subjects aged > or =40 years, with no history of stroke, and who had undergone transcranial Doppler ultrasonography (TCD) were collected prospectively. The role of classic risk factors was assessed in the presence and severity of asymptomatic ICAS, which was determined by TCD.
RESULTS
Regarding the presence of ICAS, the adjusted odds ratios (95% confidence intervals) were as follows: 1.22 (1.08-1.37) for every 10-year increase in age, 1.44 (1.08-1.91) for hypertension and 1.86 (1.33-2.59) for diabetes mellitus. No significant association was observed with regard to male sex, smoking or hyperlipidemia.
CONCLUSION
The findings suggest that age, hypertension and diabetes mellitus are significant risk factors for ICAS in asymptomatic populations.
背景
关于颅内脑动脉粥样硬化（ICAS）的危险因素，尤其是无症状人群中的危险因素，目前可用信息较少。
方法
前瞻性收集了连续1208例年龄≥40岁、无卒中病史且接受经颅多普勒超声检查（TCD）的受试者的数据。通过TCD确定无症状ICAS的存在和严重程度，评估经典危险因素在其中的作用。
结果
关于ICAS的存在情况，校正后的比值比（95%置信区间）如下：年龄每增加10岁为1.22（1.08 - 1.37），高血压为1.44（1.08 - 1.91），糖尿病为1.86（1.33 - 2.59）。未观察到男性、吸烟或高脂血症与之有显著关联。
结论
研究结果表明，年龄、高血压和糖尿病是无症状人群中ICAS的重要危险因素。
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