Danuaji Rivan, Suroto Suroto, Purwanto Bambang, Indarto Dono, Muhammad Faizal, Mirawati Diah K, Widyaningsih Vitri, Soetrisno Soetrisno, Subandi Subandi, Budianto Pepi, Hambarsari Yetty, Hamidi Baarid L, Prabaningtyas Hanindia R, Hutabarat Ervina A J, Ristinawati Ira, Tejomukti Teddy, Tedjo Raden A A
Doctoral Degree Programs of Medical Sciences Department, Faculty of Medicine, Sebelas Maret University, Surakarta, Indonesia.
Neurology Department, Faculty of Medicine, Sebelas Maret University, Surakarta, Indonesia.
J Taibah Univ Med Sci. 2022 Dec 29;18(4):771-777. doi: 10.1016/j.jtumed.2022.12.008. eCollection 2023 Aug.
A high prevalence of tobacco smoking contributes to a high incidence of acute ischemic stroke (AIS) in Indonesia. Large-artery atherosclerosis is known to be a significant cause of AIS. The present study was aimed at evaluating the association between AIS and atherosclerosis on the basis of carotid intima-media thickness (CIMT) measurements in a tertiary care hospital in Indonesia.
A total of 79 patients with AIS (case study group) and 79 individuals without AIS (control group) were included. Chi-squared tests and odds ratios were used to compare the groups and determine associations. We also considered factors such as age, body mass index (BMI), sex, type-2 diabetes mellitus (T2DM), hypertension, smoking status, dyslipidemia, socioeconomic status, and educational level in the statistical analyses. A p-value <0.05 was considered statistically significant.
Stratification of atherosclerosis into case study and control groups with respect to all study variables indicated a significant relationship (p > 0.05) between atherosclerosis and all variables except low socioeconomic status (p = 0.265) and low educational level (p = 0.180). Regression analysis demonstrated that a BMI ≥25 kg/m, compared with a normal BMI, was associated with a 2.139-fold higher risk of atherosclerosis.
AIS was associated with atherosclerosis, on the basis of CIMT measurements, according to age, BMI, sex, T2DM, hypertension, smoking status, dyslipidemia, socioeconomic status, and education level in the Indonesian population.
在印度尼西亚，吸烟率高导致急性缺血性卒中（AIS）发病率高。已知大动脉粥样硬化是AIS的一个重要病因。本研究旨在基于印度尼西亚一家三级护理医院的颈动脉内膜中层厚度（CIMT）测量结果，评估AIS与动脉粥样硬化之间的关联。
共纳入79例AIS患者（病例研究组）和79例无AIS个体（对照组）。采用卡方检验和比值比来比较两组并确定关联。在统计分析中，我们还考虑了年龄、体重指数（BMI）、性别、2型糖尿病（T2DM）、高血压、吸烟状况、血脂异常、社会经济地位和教育水平等因素。p值<0.05被认为具有统计学意义。
根据所有研究变量将动脉粥样硬化分层为病例研究组和对照组，结果表明除社会经济地位低（p = 0.265）和教育水平低（p = 0.180）外，动脉粥样硬化与所有变量之间均存在显著关系（p > 0.05）。回归分析表明，与正常BMI相比，BMI≥25 kg/m与动脉粥样硬化风险高2.139倍相关。
根据印度尼西亚人群的年龄、BMI、性别、T2DM、高血压、吸烟状况、血脂异常、社会经济地位和教育水平，基于CIMT测量结果，AIS与动脉粥样硬化相关。
