Hezova Renata, Ehrmann Jiri, Kolar Zdenek
Department of Pathology & Laboratory of Molecular Pathology, Faculty of Medicine and Dentistry, Palacky University, Hnevotinska 3, Olomouc 775 15, Czech Republic.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2007 Jun;151(1):11-5. doi: 10.5507/bp.2007.002.
WWOX (WW domain-containing oxidoreductase) gene, located on chromosome 16q 23.3-24.1 in the region recognized as the common fragile site FRA16D is considered to be a tumor suppressor gene involved in various cancers: breast, ovarian, prostate, esophageal, lung, pancreatic, gastric and hepatic. The aim of this study was to describe (i) putative protein interactions of WWOX (ii) the molecular mechanisms of tumor suppressor activity (iii) present an overview of WWOX in relation to nervous system and breast, prostate and ovarian cancers.
WWOX expression is up-regulated in endocrine organs indicating its importance in these tissues. In many cancers WWOX expression is down-regulated and low WWOX expression is related to poor prognosis.
All the evidence suggest that WWOX can be considered as a new tumor suppressor gene and target for gene therapy due to the association of high WWOX expression with improved disease free survival.
WWOX(含WW结构域的氧化还原酶)基因位于16号染色体q23.3 - 24.1区域,该区域被认为是常见脆性位点FRA16D,它被视为一种肿瘤抑制基因,涉及多种癌症:乳腺癌、卵巢癌、前列腺癌、食管癌、肺癌、胰腺癌、胃癌和肝癌。本研究的目的是描述(i)WWOX的假定蛋白质相互作用(ii)肿瘤抑制活性的分子机制(iii)概述WWOX与神经系统以及乳腺癌、前列腺癌和卵巢癌的关系。
WWOX在内分泌器官中的表达上调,表明其在这些组织中的重要性。在许多癌症中,WWOX表达下调,且低WWOX表达与预后不良相关。
所有证据表明,由于高WWOX表达与无病生存期改善相关,WWOX可被视为一种新的肿瘤抑制基因和基因治疗靶点。