Research Center of Thalassemia and Hemoglobinopathy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Department of Hematology and Blood Banking, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Cell J. 2014 Summer;16(2):99-110. Epub 2014 May 25.
Multiple myeloma (MM), is the second most common blood cancer after non-Hodgkin's lymphoma. Genetic changes, structural and numerical chromosome anomalies, are involved in pathogenesis of MM, and are among the most important prognostic factors of disease-associated patient survival. MicroRNAs (miRNAs) are small 19-22 nucleotide single-stranded RNAs involved in important cellular processes. Cytogenetic changes in plasma cells alter miRNA expression and function. MiRNAs act as tumor suppressors and oncogenes by affecting intracellular signaling pathways. MiRNA expression is associated with a specific genetic change and may assist with diagnosis and disease prognosis. This study aims to evaluate recent findings in MM-associated cytogenetic changes and their relationship with changes in the expression of miRNAs. We have determined that MM-associated cytogenetic changes are related to changes in the expression of miRNAs and CD markers (cluster of differentiation) are associated with disease survival. Information about these changes can be used for therapeutic purposes and disease prognosis.
多发性骨髓瘤（MM）是仅次于非霍奇金淋巴瘤的第二大常见血液癌。遗传改变、结构和数量染色体异常参与 MM 的发病机制，是与疾病相关的患者生存的最重要预后因素之一。微小 RNA（miRNA）是参与重要细胞过程的 19-22 个核苷酸的小单链 RNA。浆细胞的细胞遗传学改变改变了 miRNA 的表达和功能。miRNA 通过影响细胞内信号通路而作为肿瘤抑制因子和癌基因发挥作用。miRNA 的表达与特定的遗传改变相关，并可能有助于诊断和疾病预后。本研究旨在评估与 MM 相关的细胞遗传学改变及其与 miRNA 表达变化的关系。我们已经确定 MM 相关的细胞遗传学改变与 miRNA 表达的变化有关，并且 CD 标记（分化簇）与疾病的生存有关。这些变化的信息可用于治疗目的和疾病预后。
