两名血液系统恶性肿瘤患者发生自发性脾破裂。
Spontaneous splenic rupture in two patients with hematologic malignancy.
作者信息
Szotkowski Tomas, Szotkowska Romana, Pikalova Zuzana, Tichy Tomas, Flodr Patrik, Tichy Martin, Houserkova Dana, Benysek Vladimir, Zlamalova Nora, Ruzicka Vaclav, Indrak Karel
机构信息
Department of Hemato-oncology, Faculty of Medicine and Dentistry, Palacky University, University Hospital Olomouc, Czech Republic.
出版信息
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2007 Jun;151(1):113-6. doi: 10.5507/bp.2007.021.
BACKGROUND
Spontaneous splenic rupture (SSR) is a very rare complication described in several hundred patients, mainly as case reports. It is defined as a splenic rupture without antecedent injury. The authors of the present paper describe the only two SSR cases diagnosed at the Hemato-oncology department, coincidentally in one year.
PATIENTS
The first patient was admitted to hospital because of planned chemotherapy for relapsed hairy cell leukemia. The second was directed to the Hemato-oncology outpatient department because of anemia and painful splenomegaly diagnosed by a physician. The diagnose of hematologic malignancy (diffuse large B-cell lymphoma) was determined subsequently on the basis of histological examination of the spleen.
CONCLUSION
It is necessary to consider SSR not only in patients with known diagnosis of malignant disease but in the patients with negative anamnesis, too. The aim of the paper is to draw attention to the existence of this complication.
背景
自发性脾破裂（SSR）是一种极为罕见的并发症，仅有数百例相关病例报道，主要为个案报告。它被定义为无先前损伤的脾破裂。本文作者描述了血液肿瘤科在一年内偶然诊断出的仅有的两例SSR病例。
患者
首例患者因复发性毛细胞白血病计划进行化疗而入院。第二例患者因医生诊断出贫血和脾脏肿大疼痛而被转诊至血液肿瘤门诊。随后根据脾脏的组织学检查确诊为血液系统恶性肿瘤（弥漫性大B细胞淋巴瘤）。
结论
不仅要在已知患有恶性疾病的患者中考虑SSR，对于既往史阴性的患者也有必要考虑。本文旨在引起对这种并发症存在的关注。
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