Lucivero V, Prontera M, Mezzapesa D M, Petruzzellis M, Sancilio M, Tinelli A, Di Noia D, Ruggieri M, Federico F
Department of Neurological and Psychiatric Sciences, University of Bari, Piazza G. Cesare 12, 1-70124, Bari, Italy.
Neurol Sci. 2007 Aug;28(4):165-70. doi: 10.1007/s10072-007-0814-0. Epub 2007 Aug 10.
Accumulating data suggest that matrix metalloproteinases (MMPs), in particular MMP-2 and MMP-9, are deleterious after acute ischaemic stroke. A beneficial effect of MMPs in the repairing phases of cerebral ischaemia has also been proposed. This study investigated the relationship between MMP-2 and MMP-9 and stroke subtypes, clinical recovery and haemorrhagic transformation (HT). We measured MMP-9 and MMP-2 plasma levels in 29 patients with ischaemic stroke at days one and seven. MMP-2 levels increased only in lacunar strokes, whilst MMP-9 increased only in patients with more severe stroke. Basal MMP-2 levels were higher in patients with stable or recovering symptoms whilst MMP-9 values at day seven were correlated with worse clinical outcome. No differences related to the presence of HT were found. This study sustains a different behaviour of MMPs after ischaemic stroke. MMP-2 seems to be expressed early and related to better outcome, whilst MMP-9 seems to be late and related to more severe stroke.
越来越多的数据表明，基质金属蛋白酶（MMPs），尤其是MMP-2和MMP-9，在急性缺血性中风后具有有害作用。也有人提出MMPs在脑缺血修复阶段具有有益作用。本研究调查了MMP-2和MMP-9与中风亚型、临床恢复及出血性转化（HT）之间的关系。我们在第1天和第7天测量了29例缺血性中风患者的血浆MMP-9和MMP-2水平。MMP-2水平仅在腔隙性中风中升高，而MMP-9仅在病情较重的中风患者中升高。症状稳定或正在恢复的患者基础MMP-2水平较高，而第7天的MMP-9值与较差的临床结局相关。未发现与HT存在相关的差异。本研究支持缺血性中风后MMPs的不同表现。MMP-2似乎早期表达且与较好的结局相关，而MMP-9似乎表达较晚且与更严重的中风相关。
