Kachi T, Sobue G, Yamada T, Tamura T, Ando K
Department of Neurology, Chubu National Hospital.
Rinsho Shinkeigaku. 1991 Sep;31(9):1029-31.
Central motor conduction time (CMCT) from the cerebral motor cortex to the cervical segment of the spinal cord (C-CMCT) and CMCT from the cortex to the lumbar segment of the spinal cord (L-CMCT) were estimated using percutaneous electrical cortical, cervical and lumbar stimulation in 8 patients with pseudopolyneuritic form of amyotrophic lateral sclerosis (ALS). The results were compared to those in 18 patients with bulbar and common forms of ALS and 13 normal control subjects. Both the C-CMCT and the L-CMCT were remarkably prolonged in pseudopolyneuritic form of ALS as well as in bulbar and common forms of ALS. These results were consistent with the morphological findings that the large myelinated fibres in the corticospinal tract are depleted in pseudopolyneuritic form of ALS in which deep tendon reflexes are hypoactive and pyramidal sings are not obvious. The evaluation of CMCT is suggested to be useful for diagnosis of ALS in which upper motor neurone disorder is not manifested.
在8例假多神经炎型肌萎缩侧索硬化症（ALS）患者中，采用经皮电刺激大脑运动皮层、颈部和腰部的方法，估算从大脑运动皮层到脊髓颈段的中枢运动传导时间（C-CMCT）以及从皮层到脊髓腰段的中枢运动传导时间（L-CMCT）。将结果与18例延髓型和普通型ALS患者以及13名正常对照者的结果进行比较。在假多神经炎型ALS以及延髓型和普通型ALS中，C-CMCT和L-CMCT均显著延长。这些结果与形态学发现一致，即在假多神经炎型ALS中，皮质脊髓束中的大髓鞘纤维减少，其中深部腱反射减弱且锥体束征不明显。对于未表现出上运动神经元障碍的ALS诊断，CMCT评估被认为是有用的。
