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危重症患者补充硒：好事过头会成坏事吗？

Selenium supplementation in critically ill patients: can too much of a good thing be a bad thing?

作者信息

Heyland Daren K

出版信息

Crit Care. 2007;11(4):153. doi: 10.1186/cc5975.

DOI:10.1186/cc5975
PMID:17692136
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2206521/
Abstract

A recent study by Forceville and colleagues evaluated the effect of high-dose selenium administration as a treatment for septic shock. The study was negative and conflicts with existing clinical data regarding selenium administration in critically ill patients. Perhaps the key to understanding the differences between these discrepant observations lies in considering the dose and timing of selenium administration.

摘要

福尔茨维尔及其同事最近进行的一项研究评估了大剂量补充硒作为治疗感染性休克的效果。该研究结果为阴性，且与现有关于危重症患者补充硒的临床数据相矛盾。或许理解这些相互矛盾观察结果之间差异的关键在于考虑补充硒的剂量和时机。

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2
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硒剂治疗严重脓毒症或感染性休克的影响：一项随机对照试验的荟萃分析。
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