Seyer-Hansen M, Andreassen T T, Oxlund H, Jørgensen P H
Department of Connective Tissue Biology, University of Aarhus, Denmark.
Connect Tissue Res. 1991;26(3):181-6. doi: 10.3109/03008209109152436.
The mechanical strength of skin wounds as well as the deposition of hydroxyproline and KB3H4 reducible hydroxylysinonorleucine (HLNL) and dihydroxylysinonorleucine (DHLNL) cross-links in subcutaneously implanted cellulose sponges have been investigated in rats treated with aminoguanidine (AG) or beta-aminopropionitrile (BAPN). Treatment with AG (25 mg/kg BW/day) did not influence the mechanical strength of the wounds, the deposition of hydroxyproline or the pattern of reducible collagen cross-links, whereas AG (125 mg/kg BW/day) reduced the maximum load by 17%, but did not influence the deposition of hydroxyproline or reducible cross-linking pattern. Treatment with BAPN (333 mg/kg BW/day) reduced the strength of the wounds by 59%, the HLNL by 50% and the DHLNL 57%, whereas the deposition of hydroxyproline did not seem to be influenced by BAPN treatment. In conclusion, AG at moderate dosage does not seem to influence the formation of lysyl oxidase dependent reducible cross-links of collagen.
在接受氨基胍（AG）或β-氨基丙腈（BAPN）治疗的大鼠中，研究了皮肤伤口的机械强度以及皮下植入的纤维素海绵中羟脯氨酸的沉积、KB3H4可还原的羟赖氨酰正亮氨酸（HLNL）和二羟赖氨酰正亮氨酸（DHLNL）交联的情况。用AG（25毫克/千克体重/天）治疗不影响伤口的机械强度、羟脯氨酸的沉积或可还原胶原交联的模式，而AG（125毫克/千克体重/天）使最大负荷降低了17%，但不影响羟脯氨酸的沉积或可还原交联模式。用BAPN（333毫克/千克体重/天）治疗使伤口强度降低了59%，HLNL降低了50%，DHLNL降低了57%，而羟脯氨酸的沉积似乎不受BAPN治疗的影响。总之，中等剂量的AG似乎不影响赖氨酰氧化酶依赖性胶原可还原交联的形成。
