Synthesis of novel HIV protease inhibitors (PI) with activity against PI-resistant virus.

作者信息

Raghavan Subharekha, Lu Zhijian, Beeson Teresa, Chapman Kevin T, Schleif William A, Olsen David B, Stahlhut Mark, Rutkowski Carrie A, Gabryelski Lori, Emini Emilio, Tata James R

机构信息

Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA.

出版信息

Bioorg Med Chem Lett. 2007 Oct 1;17(19):5432-6. doi: 10.1016/j.bmcl.2007.07.040. Epub 2007 Jul 31.

DOI:10.1016/j.bmcl.2007.07.040

PMID:17692518

Abstract

A series of HIV protease inhibitors with modifications on the P3 position have been designed and synthesized. These compounds exhibit excellent antiviral activity against both the wild type enzyme and PI-resistant clinical viral isolates. The synthesis and biological activity of the compounds are described.

摘要

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