针对对蛋白酶抑制剂（PI）耐药病毒的口服生物可利用的高效HIV蛋白酶抑制剂。
Orally bioavailable highly potent HIV protease inhibitors against PI-resistant virus.
作者信息
Lu Zhijian, Bohn Joann, Rano Tom, Rutkowski Carrie A, Simcoe Amy L, Olsen David B, Schleif William A, Carella Anthony, Gabryelski Lori, Jin Lixia, Lin Jiunn H, Emini Emilio, Chapman Kevin, Tata James R
机构信息
Department of Basic Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA.
出版信息
Bioorg Med Chem Lett. 2005 Dec 1;15(23):5311-4. doi: 10.1016/j.bmcl.2005.08.072. Epub 2005 Oct 3.
Efforts directed to identifying potent HIV protease inhibitors (PI) have yielded a class of compounds that are not only very active against wild-type (NL4-3) HIV virus but also very potent against a panel of PI-resistant viral isolates. Chemistry and biology are described.
致力于鉴定强效HIV蛋白酶抑制剂（PI）的研究工作已产生了一类化合物，这类化合物不仅对野生型（NL4-3）HIV病毒具有很高的活性，而且对一组耐PI的病毒分离株也具有很强的效力。文中描述了其化学性质和生物学特性。
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