Dorkov Petar, Pantcheva Ivayla N, Sheldrick William S, Mayer-Figge Heike, Petrova Rositza, Mitewa Mariana
Department of Analytical Chemistry, Faculty of Chemistry, Sofia University, 1, J. Bourchier Blvd., 1164 Sofia, Bulgaria.
J Inorg Biochem. 2008 Jan;102(1):26-32. doi: 10.1016/j.jinorgbio.2007.06.033. Epub 2007 Jul 1.
Mononuclear neutral manganese(II) and cobalt(II) complexes with the antibiotic Sodium Monensin A (Mon-Na, 1b) were synthesized and characterized. The crystal structures of M(Mon-Na)2Cl2.H2O (M=Mn, 2; M=Co, 3) were determined by X-ray crystallography. The complexes crystallize in monoclinic space group C2 with a tetrahedrally coordinated transition metal attached to oxygen atoms of deprotonated carboxyl groups of two Sodium Monensin molecules and two chloride ions. The sodium ion remains in the cavity of the ligand and cannot be replaced by Mn(II) or Co(II). The complexes were additionally characterized by different spectroscopic techniques (UV-Visible, EPR, FAB-MS). A preferable octahedral environment around the transition metal centers is observed in polar solvents while the complexes retain their tetrahedral structure in non-polar media. The antimicrobial activity of 1b, 2 and 3 was tested against Gram(+) and Gram(-) bacteria.
合成并表征了单核中性锰(II)和钴(II)与抗生素莫能菌素A钠(Mon-Na,1b)形成的配合物。通过X射线晶体学确定了M(Mon-Na)2Cl2·H2O(M = Mn,2;M = Co,3)的晶体结构。这些配合物在单斜晶系空间群C2中结晶,过渡金属以四面体配位形式与两个莫能菌素钠分子去质子化羧基的氧原子以及两个氯离子相连。钠离子保留在配体的腔内,不能被Mn(II)或Co(II)取代。还通过不同的光谱技术(紫外可见光谱、电子顺磁共振光谱、快原子轰击质谱)对这些配合物进行了表征。在极性溶剂中观察到过渡金属中心周围存在更优选的八面体环境,而这些配合物在非极性介质中保持其四面体结构。测试了1b、2和3对革兰氏阳性菌和革兰氏阴性菌的抗菌活性。