Dimiza Filitsa, Hatzidimitriou Antonios G, Psomas George
Department of General and Inorganic Chemistry, Faculty of Chemistry, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece.
Int J Mol Sci. 2024 Dec 16;25(24):13457. doi: 10.3390/ijms252413457.
Nine manganese(II) complexes with a series of non-steroidal anti-inflammatory drugs (namely sodium diclofenac, diflunisal, flufenamic acid, sodium meclofenamate, mefenamic acid, and tolfenamic acid) were prepared in the presence of diverse nitrogen donors, i.e., pyridine, 1,10-phenanthroline, 2,2'-bipyridine and neocuproine, as co-ligands and were characterized with spectroscopic techniques and single-crystal X-ray crystallography. The biological profile of the resultant complexes was investigated regarding their antioxidant potency and their interaction with DNA and serum albumins. The complexes interact with calf-thymus DNA in an intercalative mode and bind tightly and reversibly to human and bovine serum albumins studied. In order to assess the antioxidant activity of the Mn(II) complexes, their ability to scavenge 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) free radicals was monitored.
在多种含氮供体（即吡啶、1,10-菲咯啉、2,2'-联吡啶和新亚铜试剂）作为共配体存在的情况下，制备了九种含有一系列非甾体抗炎药（即双氯芬酸钠、二氟尼柳、氟芬那酸、甲氯芬那酸钠、甲芬那酸和托芬那酸）的锰（II）配合物，并用光谱技术和单晶X射线晶体学对其进行了表征。研究了所得配合物的生物学特性，包括它们的抗氧化能力以及与DNA和血清白蛋白的相互作用。这些配合物以插入模式与小牛胸腺DNA相互作用，并与所研究的人血清白蛋白和牛血清白蛋白紧密且可逆地结合。为了评估锰（II）配合物的抗氧化活性，监测了它们清除2,2'-偶氮二（3-乙基苯并噻唑啉-6-磺酸）自由基的能力。
