微波辅助合成取代六氢吡咯并[3,2-c]喹啉
Microwave-assisted synthesis of substituted hexahydro-pyrrolo[3,2-c]quinolines.
作者信息
Neuschl Michal, Bogdal Darek, Potacek Milan
机构信息
Department of Organic Chemistry, Masaryk University, Kotlarska 2, Brno, Czech Republic.
出版信息
Molecules. 2007 Jan 24;12(1):49-59. doi: 10.3390/12010049.
Abstract
New compounds with the ethyl hexahydro-1H-pyrrolo[3,2-c]quinoline-2-carboxylate skeleton were prepared by microwave-assisted intramolecular 1,3-dipolar cycloaddition reactions. The reactions were carried out under solvent-free conditions and compared with the same reaction in the presence of a solvent and a catalyst. Steric effects on the selectivity of the reaction were noted and evaluated.
摘要
通过微波辅助分子内1,3-偶极环加成反应制备了具有六氢-1H-吡咯并[3,2-c]喹啉-2-羧酸乙酯骨架的新型化合物。该反应在无溶剂条件下进行，并与在有溶剂和催化剂存在下的相同反应进行了比较。记录并评估了空间效应对反应选择性的影响。
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