School of Chemistry and Chemical Engineering, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University , Xuzhou Jiangsu 221116, P. R. China.
ACS Comb Sci. 2013 Sep 9;15(9):498-502. doi: 10.1021/co400073m. Epub 2013 Aug 16.
A combinatorial synthesis of pyrrolo[3,2-f]quinoline and pyrrolo[3,2-a]acridine derivatives is described as a three-component reaction of aromatic aldehyde, 1H-indol-5-amine, and 1,3-dicarbonyl compounds under catalyst-free conditions. The 1,3-dicarbonyl compounds include 5,5-dimethylcyclohexane-1,3-dione, cyclopentane-1,3-dione, and 2H-indene-1,3-dione. It is interesting that the designed reactions gave aromatized or unaromatized products, which depend on the reaction temperature and reactants of 1,3-dicarbonyl compounds.
描述了一种通过无催化剂条件下的芳香醛、1H-吲哚-5-胺和 1,3-二羰基化合物的三组分反应，合成吡咯并[3,2-f]喹啉和吡咯并[3,2-a]吖啶衍生物的方法。1,3-二羰基化合物包括 5,5-二甲基环己烷-1,3-二酮、环戊烷-1,3-二酮和 2H-茚-1,3-二酮。有趣的是，设计的反应得到了芳构化或非芳构化的产物，这取决于反应温度和 1,3-二羰基化合物的反应物。
