Bayles Kenneth W
Department of Pathology & Microbiology, University of Nebraska Medical Center, 986,495 Nebraska Medical Center, Omaha, Nebraska, USA.
Nat Rev Microbiol. 2007 Sep;5(9):721-6. doi: 10.1038/nrmicro1743.
Recent studies have revealed that the regulated death of bacterial cells is important for biofilm development. Following cell death, a sub-population of the dead bacteria lyse and release genomic DNA, which then has an essential role in intercellular adhesion and biofilm stability. This Opinion focuses on the role of regulated cell death and lysis in biofilm development and provides a functional comparison between bacterial programmed cell death and apoptosis. The hypothesis that the differential regulation of these processes during biofilm development contributes to the antibiotic tolerance of biofilm cells is also explored.
最近的研究表明，细菌细胞的程序性死亡对生物膜形成很重要。细胞死亡后，一部分死亡细菌会裂解并释放基因组DNA，这些DNA随后在细胞间黏附和生物膜稳定性中发挥重要作用。本观点聚焦于程序性细胞死亡和裂解在生物膜形成中的作用，并对细菌程序性细胞死亡和细胞凋亡进行了功能比较。还探讨了生物膜形成过程中这些过程的差异调节有助于生物膜细胞产生抗生素耐受性的假说。
