Schneider B V, Hohl D, Schnyder U W
Department of Dermatology, University Hospital, Zurich, Switzerland.
Dermatologica. 1991;183(1):73-6.
A 32-year-old Turkish man with a progressive appearance of indolent, skin-colored nodules on the trunk and proximal extremities is presented. Clinical and laboratory examinations did not reveal any other relevant abnormalities. Histological specimens showed focal, ill-defined depositions of acid mucopolysaccharides mainly in the reticular dermis. Collagen fibers were split up and separated. Ultrastructurally, activated fibroblasts and an increased synthesis of collagen fibrils and elastic microfibrils as well as numerous macrophages were noticed. Diagnostically, an unusual multiple type of cutaneous focal mucinosis is most likely.
本文介绍了一名32岁的土耳其男子，其躯干和近端肢体逐渐出现无痛性、肤色结节。临床和实验室检查未发现任何其他相关异常。组织学标本显示酸性粘多糖主要在网状真皮中呈局灶性、边界不清的沉积。胶原纤维被劈开并分离。超微结构上，可见活化的成纤维细胞、胶原纤维和弹性微纤维合成增加以及大量巨噬细胞。诊断上，最有可能是一种不寻常的多发型皮肤局灶性粘蛋白病。
