Alho Hanni S, Maasilta Paula K, Vainikka Tiina, Salminen Ulla-Stina
Department of Surgery, Helsinki University Hospital, Helsinki, Finland.
Exp Lung Res. 2007 Aug;33(6):303-20. doi: 10.1080/01902140701539745.
The expression of platelet-derived growth factor (PDGF), transforming growth factor (TGF)-beta, and connective tissue growth factor (CTGF) and the effect of imatinib, an agent inhibiting PDGF receptors, were assessed in a porcine bronchial transplantation model of obliterative bronchiolitis (OB). Up-regulation of PDGF-A, PDGF receptors alpha and beta, and TGF-beta expression occurred in allografts, whereas PDGF-B and CTGF expression was similar in allo- and autografts. Imatinib modified the inflammatory responses and expression patterns of PDGF-A and PDGF receptors. This study further confirms PDGF and TGF-beta as mediators of OB and supports the concept of the importance of the pathways signaled through PDGF receptors in post-transplant OB.
在闭塞性细支气管炎（OB）的猪支气管移植模型中，评估了血小板衍生生长因子（PDGF）、转化生长因子（TGF）-β和结缔组织生长因子（CTGF）的表达以及抑制PDGF受体的药物伊马替尼的作用。同种异体移植物中PDGF-A、PDGF受体α和β以及TGF-β表达上调，而同种异体和自体移植物中PDGF-B和CTGF表达相似。伊马替尼改变了炎症反应以及PDGF-A和PDGF受体的表达模式。本研究进一步证实PDGF和TGF-β是OB的介质，并支持通过PDGF受体发出信号的通路在移植后OB中的重要性这一概念。
