Connolly Nancy C, Colleton Bonnie A, Rinaldo Charles R
University of Pittsburgh, School of Medicine and Graduate School of Public Health, 204 Craft Avenue, B501, Pittsburgh, PA 15213, USA.
Curr Opin Mol Ther. 2007 Aug;9(4):353-63.
The orchestration of a coordinated immune response by dendritic cells (DCs) make them an attractive target for pathogens to exploit to evade host immunity, as well as for use in therapeutic strategies to overcome this exploitation. Because HIV-1 infection is predominantly a disease of the immune system, targeting DCs for therapeutic strategies to counter the effects of HIV-1 on DCs and other immune effector cells is a timely and extremely dynamic endeavor. Our knowledge of DC function and the interaction between HIV-1 and DCs is rapidly increasing. This review focuses on HIV-1-DC interactions, the impact of these on DC therapeutics for the treatment of HIV-1-infected individuals and the current status of DC-based therapeutic vaccines for HIV-1 infection.
树突状细胞（DCs）对协调免疫反应的调控，使其成为病原体利用以逃避宿主免疫的诱人靶点，同时也成为用于克服这种利用的治疗策略中的靶点。由于HIV-1感染主要是一种免疫系统疾病，针对DCs采取治疗策略以对抗HIV-1对DCs和其他免疫效应细胞的影响，是一项及时且极具活力的工作。我们对DC功能以及HIV-1与DCs之间相互作用的了解正在迅速增加。本综述聚焦于HIV-1与DCs的相互作用、这些相互作用对治疗HIV-1感染个体的DC疗法的影响以及基于DC的HIV-1感染治疗性疫苗的现状。
