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[西班牙巴伦西亚自治区血小板抗聚集剂的使用趋势(2000 - 2005年)]

[Trend in platelet antiaggregants utilization in the autonomous community of Valencia, Spain (2000-2005)].

作者信息

Román Llamosí Beatriz, Broseta Solaz Rocío, Quilés Izquierdo Joan, Ubeda Pascual Amalia

机构信息

Departamento Farmacología, Universitat de Valencia, España.

出版信息

Rev Esp Salud Publica. 2007 May-Jun;81(3):279-87. doi: 10.1590/s1135-57272007000300005.

DOI:10.1590/s1135-57272007000300005
PMID:17694635
Abstract

BACKGROUND

Platelet antiaggregants are basic drugs for preventing ischemic arterial diseases. This study is aimed at ascertaining the trend in their use in Primary Care in the Autonomous Community of Valencia during the 2000-2005 period.

METHODS

Descriptive study of the use of platelet antiaggregants (ATC code: B01AC) dispensed charged to the National Health System in the Autonomous Community of Valencia in Primary Care. Data given in defined daily doses (DDD) per 1000 inhabitants per day.

RESULTS

In 2005, three drugs totalled 98% of all those prescribed overall (acetyl salicylicacid (ASA) 66%, clopidogrel 23% and triflusal 9%). Oral antiaggregant use rose by 23% within the 2000-2005 period (from 29.6 to 36.5 DDD/1000 inhab./day). Clopidogrel showed a 218% increase, whilst ASA was the most used drug, with quite a stable percentage of use throughout said time period (nearing 70%). The expense generated by this group of drugs doubled, clopidogrel having been the highest-cost drug/DDD (2.14 EUROS), its use having totalled 23% of all antiaggregants yet the expense thereof having totalled 76% of the total expenditure.

CONCLUSIONS

The use of antiaggregants increased in the Autonomous Community of Valencia during the time period under study. The utilization of ASA remained stable, whilst clopidogrel increased its market share despite the treatment guide recommendations and the restrictions on its use. The consumption of clopidogrel noticeably contributed to the drug spending for this group.

摘要

背景

血小板抗聚集剂是预防缺血性动脉疾病的基础药物。本研究旨在确定2000 - 2005年期间巴伦西亚自治区初级医疗中血小板抗聚集剂的使用趋势。

方法

对巴伦西亚自治区初级医疗中记入国家卫生系统账目的血小板抗聚集剂(解剖学治疗学及化学分类代码:B01AC)的使用情况进行描述性研究。数据以每千居民每日限定日剂量(DDD)给出。

结果

2005年,三种药物总计占所有处方药物的98%(乙酰水杨酸(ASA)占66%,氯吡格雷占23%,曲氟尿苷占9%)。在2000 - 2005年期间,口服抗聚集剂的使用量增加了23%(从29.6增至36.5 DDD/1000居民/天)。氯吡格雷增长了218%,而ASA是使用最多的药物,在整个时间段内其使用比例相当稳定(接近70%)。这类药物产生的费用翻倍,氯吡格雷是成本最高的药物/DDD(2.14欧元),其使用量占所有抗聚集剂的23%,但其费用却占总支出的76%。

结论

在所研究的时间段内,巴伦西亚自治区抗聚集剂的使用有所增加。ASA的使用保持稳定,而氯吡格雷尽管有治疗指南的建议及其使用限制,但其市场份额仍有所增加。氯吡格雷的消费显著增加了该类药物的支出。

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