Kaewrudee Srinaree, Anuwutnavin Sanitra, Kanpittaya Jaturat, Soontrapa Sugree, Sakondhavat Chuanchum
Department of Obstetrics and Gynecology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
J Reprod Med. 2007 Jun;52(6):513-20.
To assess the different effects between non-treatment, estrogen and estrogen-progestin regimens on changes in mammographic density in postmenopausal women.
A historical cohort of 105 postmenopausal women who attended the Menopause Clinic, Srinagarind Hospital, Khon Kaen, Thailand, and received 1 of 3 regimens: nontreatment, estrogen or estrogen-progestin (35 in each group). Mammographic examinations were done before and after a 12-24-month period of hormone therapy. Breast density (mammographic density, recorded in the medical records) between the 2 examinations in each group were compared.
An increase in mammographic density occurred among women receiving hormone therapy: 40% (14 of 35) in the estrogen-progestin group and 20% (7 of 35) in the estrogen-only group, but no variation in density was observed in the nontreatment group. The increase in mammographic density occurring in women on hormone therapy, as compared to the nontreatment group, was statistically significant (estrogen-progestin, 95% CI 20.91-59.09; estrogen, 95% CI 3.89-36.11). When the different treatment types were compared, the estrogen-progestin group tended to have a higher prevalence of mammographic density change than the estrogen-only group, but the difference was not statistically significant (95% CI -3.81-43.81).
Hormone therapy was associated with increased mammographic density. Apparently the estrogen-progestin regimen affects breast density more than estrogen-only does.
评估非治疗、雌激素及雌激素 - 孕激素方案对绝经后女性乳腺X线密度变化的不同影响。
一项历史性队列研究，纳入了105名绝经后女性，她们在泰国孔敬府诗里那琳医院绝经门诊就诊，并接受了三种方案中的一种：非治疗、雌激素或雌激素 - 孕激素治疗（每组35人）。在进行12 - 24个月的激素治疗前后进行了乳腺X线检查。比较了每组两次检查之间的乳房密度（记录在病历中的乳腺X线密度）。
接受激素治疗的女性乳腺X线密度增加：雌激素 - 孕激素组为40%（35人中的14人），仅雌激素组为20%（35人中的7人），而未治疗组未观察到密度变化。与未治疗组相比，接受激素治疗的女性乳腺X线密度增加具有统计学意义（雌激素 - 孕激素组，95%CI 20.91 - 59.09；雌激素组，95%CI 3.89 - 36.11）。当比较不同治疗类型时，雌激素 - 孕激素组乳腺X线密度变化的患病率往往高于仅雌激素组，但差异无统计学意义（95%CI -3.81 - 43.81）。
激素治疗与乳腺X线密度增加有关。显然，雌激素 - 孕激素方案对乳房密度的影响比仅使用雌激素更大。
