乳腺X线密度与激素治疗持续时间的关系：雌激素及雌孕激素的影响
The relationship between mammographic density and duration of hormone therapy: effects of estrogen and estrogen-progestin.
作者信息
Chen Fang-Ping, Cheung Yun-Chung, Teng Li-Fen, Soong Yung-Kui
机构信息
Department of Obstetrics and Gynecology and Department of Radiology, Keelung Chang Gung Memorial Hospital, Keelung, Taiwan, ROC.
出版信息
Hum Reprod. 2005 Jun;20(6):1741-5. doi: 10.1093/humrep/deh820. Epub 2005 Apr 21.
BACKGROUND
The purpose of this study was to examine the effects of duration of hormone therapy (HT) and treatment regimens on mammographic density.
METHODS
A retrospective study was carried out of of 467 post-menopausal women who received estrogen or estrogen-progestin and had regular mammographic density determination by the Breast Imaging Reporting and Data System between 1994 and 2001.
RESULTS
The fraction of women using HT who had an increase in mammographic density became more important over time. Further analysis of the effects of regimens after 4 years of HT shows that the increase in mean density was much greater in women receiving combined HT than in those receiving estrogen alone. The incidence of increased mammographic density showed significantly progressive increases over the duration of combined HT from 7.5 to 22.4%.
CONCLUSIONS
Although most women using HT maintained breast density at pre-treatment levels, there is a note of caution for women using long-term HT, especially those using combined estrogen-progestin.
背景
本研究旨在探讨激素治疗（HT）的持续时间和治疗方案对乳房X线密度的影响。
方法
对467名绝经后妇女进行回顾性研究，这些妇女在1994年至2001年间接受了雌激素或雌激素 - 孕激素治疗，并通过乳腺影像报告和数据系统定期进行乳房X线密度测定。
结果
随着时间的推移，使用HT且乳房X线密度增加的女性比例变得更加显著。对HT治疗4年后方案效果的进一步分析表明，接受联合HT的女性平均密度的增加远大于仅接受雌激素的女性。在联合HT治疗期间，乳房X线密度增加的发生率从7.5%显著逐步增加至22.4%。
结论
虽然大多数使用HT的女性将乳房密度维持在治疗前水平，但对于长期使用HT的女性，尤其是使用雌激素 - 孕激素联合治疗的女性，需谨慎对待。
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