Solari Nicola, Acquati Mirko, Queirolo Paola, Stella Mattia, Di Somma Carmine, Truini Mauro, Cafiero Ferdinando
Division of Surgical Oncology, National Cancer Research Institute of Genoa, Italy.
Anticancer Res. 2007 Jul-Aug;27(4C):2849-53.
Primary melanoma of the esophagus is a very rare and aggressive neoplasm; only a small number of patients survive more than 1 year after initial diagnosis.
We describe a case of primary melanoma of the esophagus in a woman with a history of invasive breast cancer. The patient suffered from dysphagic and dyspeptic disorders. The abdomen ultrasonography and the esophagogastroscopy showed a lesion located at the esophago-gastric junction extending to the gastric fundus. Histological and immunohistochemical studies revealed a primary esophageal infiltrating melanoma. A total gastrectomy and regional lymphadenectomy with a partial resection of the distal esophagus was performed.
During laparotomic exploration, numerous dark lymp hnodes were found. On frozen sections, surprisingly neither malignant cells nor melanin were detected in the lymph nodes. Resection margins were not involved with the tumor.
Patient is still alive with no evidence of recurrence at 24 months after surgical treatment, alone.
原发性食管黑色素瘤是一种非常罕见且侵袭性强的肿瘤；初诊后仅有少数患者能存活超过1年。
我们描述了一例患有浸润性乳腺癌病史的女性原发性食管黑色素瘤病例。患者有吞咽困难和消化不良症状。腹部超声和食管胃镜检查显示病变位于食管胃交界处并延伸至胃底。组织学和免疫组化研究显示为原发性食管浸润性黑色素瘤。行全胃切除术、区域淋巴结清扫术及食管远端部分切除术。
剖腹探查时发现许多深色淋巴结。冰冻切片检查时，令人惊讶的是在淋巴结中未检测到恶性细胞和黑色素。切除边缘未受累于肿瘤。
手术治疗后24个月，患者仍存活，无复发迹象。
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