Liebl L S, Elson F, Quaas A, Gawad K A, Izbicki J R
Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
Anticancer Res. 2007 Jul-Aug;27(4C):2897-902.
Pulmonary metastasectomy in soft tissue sarcoma (STS) can lead to long-term survival. The aim of our study was to report on prognostic factors and the value of repeat resection in recurrent disease.
Seventy-eight pulmonary metastasectomies were performed on 42 STS patients from 1990 to 2005. Overall survival time and 3-year survival rate were evaluated. Subgroup analysis was performed on age, primary tumor stage, histological type and grade, occurrence and recurrence pattern, systemic treatment and number of resections.
The 3-year actuarial survival rate was 31%. Primary tumor grade and repeat resections were shown to be independent prognostic factors for survival.
Patients with repeat resections due to recurrent metastasis show a significantly better prognosis than those with only one resection. Thus, lacking randomised controlled data of the natural course of patients with unresected lung metastases to compare these results, metastasectomy in STS patients is also recommended in recurrent disease.
软组织肉瘤（STS）肺转移瘤切除术可带来长期生存。我们研究的目的是报告复发疾病的预后因素及再次切除的价值。
1990年至2005年期间，对42例STS患者实施了78次肺转移瘤切除术。评估总生存时间和3年生存率。对年龄、原发肿瘤分期、组织学类型和分级、发生及复发模式、全身治疗和切除次数进行亚组分析。
3年精算生存率为31%。原发肿瘤分级和再次切除被证明是生存的独立预后因素。
因复发转移而接受再次切除的患者预后明显好于仅接受一次切除的患者。因此，由于缺乏未切除肺转移瘤患者自然病程的随机对照数据来比较这些结果，对于复发性疾病，也建议对STS患者进行肺转移瘤切除术。
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