原发性肿瘤切除对骨肉瘤和软组织肉瘤患者肺转移的影响。
Impact of Primary Tumor Resection on Metastasis to the Lung in Patients With Bone and Soft-tissue Sarcoma.
作者信息
Tsuchie Hiroyuki, Emori Makoto, Nagasawa Hiroyuki, Murahashi Yasutaka, Mizushima Emi, Shimizu Junya, Yamashita Toshihiko, Miyakoshi Naohisa
机构信息
Department of Orthopedic Surgery, Akita University Graduate School of Medicine, Akita, Japan;
Department of Orthopedic Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan.
出版信息
In Vivo. 2021 Nov-Dec;35(6):3467-3473. doi: 10.21873/invivo.12647.
BACKGROUND
Few reports have investigated the effect of primary tumor resection on lung metastasis and prognosis in patients with bone and soft-tissue sarcoma, and we evaluated its effect on lung metastasis and prognosis.
PATIENTS AND METHODS
We retrospectively identified patients with lung metastasis from bone and soft-tissue sarcoma. We examined the factors affecting prognosis and the rate of lung metastasis increase.
RESULTS
A total of 48 patients were included. The multivariate analysis revealed that poor prognosis was significantly associated with a large maximum diameter of lung metastasis at the first visit and a rapid rate of increase (p=0.0400 and p=0.0003, respectively). The multivariate logistic regression analysis revealed that the rate of increase of size of lung metastases was only significantly associated with a large maximum diameter at the first visit (p=0.0245).
CONCLUSION
Primary tumor resection of bone and soft-tissue sarcoma in patients with lung metastasis was not shown to affect their prognosis.
背景
很少有报告研究原发性肿瘤切除对骨与软组织肉瘤患者肺转移及预后的影响，我们评估了其对肺转移及预后的影响。
患者与方法
我们回顾性地确定了骨与软组织肉瘤肺转移患者。我们研究了影响预后的因素以及肺转移增加率。
结果
共纳入48例患者。多因素分析显示，预后不良与首次就诊时肺转移灶的最大直径较大及增长速度较快显著相关（分别为p = 0.0400和p = 0.0003）。多因素逻辑回归分析显示，肺转移灶大小的增加率仅与首次就诊时的最大直径较大显著相关（p = 0.0245）。
结论
肺转移的骨与软组织肉瘤患者进行原发性肿瘤切除未显示会影响其预后。
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