脂肪酸合酶在胰腺癌中的免疫组化表达及预后意义
Immunohistochemical expression and prognostic significance of fatty acid synthase in pancreatic carcinoma.
作者信息
Alo Piero L, Amini Mostafa, Piro Francesca, Pizzuti Laura, Sebastiani Valeria, Botti Claudio, Murari Riccardo, Zotti Giancarlo, Di Tondo Ugo
机构信息
Department of Experimental Pathology and Medicine, University of Rome "La Sapienza", Rome, Italy.
出版信息
Anticancer Res. 2007 Jul-Aug;27(4B):2523-7.
BACKGROUND
The aim of this study was to evaluate immunohistochemical markers in pancreatic cancer and to determine the association of their expression with clinicopathological features and prognosis.
PATIENTS AND METHODS
Thirty pancreatic adenocarcinoma patients were followed-up for an average period of 5 years. FAS, bcl-2, p53 and Ki-67 expression were detected immunohistochemically to determine their prognostic value.
RESULTS
FAS was statistically associated with p53 (p = 0.002), Ki-67 (p = 0.003), higher histological grade (p = 0.001 and recurrence and overall survival (p = 0.001).
CONCLUSION
The newly found overexpression of FAS in highly aggressive pancreatic carcinomas may help us stratify patients into different prognostic groups and indicate new therapeutic strategies.
背景
本研究旨在评估胰腺癌中的免疫组化标志物，并确定其表达与临床病理特征及预后的关联。
患者与方法
对30例胰腺腺癌患者进行了平均5年的随访。采用免疫组化方法检测FAS、bcl-2、p53和Ki-67的表达，以确定其预后价值。
结果
FAS与p53（p = 0.002）、Ki-67（p = 0.003）、更高的组织学分级（p = 0.001）以及复发和总生存期（p = 0.001）存在统计学关联。
结论
新发现的FAS在高侵袭性胰腺癌中的过表达可能有助于我们将患者分层到不同的预后组，并指示新的治疗策略。
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