Takizawa Jun, Aoki Sadao, Kurasaki Tori, Higashimura Masutaka, Honma Keiichiro, Kitajima Toshiki, Momoi Akihito, Takahashi Hidenobu, Nakamura Naoya, Furukawa Tatsuo, Aizawa Yoshifusa
Division of Hematology, Niigata University Graduate School of Medical and Dental Science, Niigata, Japan.
Am J Hematol. 2007 Dec;82(12):1113-5. doi: 10.1002/ajh.21042.
This study reports the first well-documented case of adult T-cell leukemia (ATL) successfully treated with unrelated cord blood transplantation (UCBT). A 49-year-old woman was diagnosed with acute-type of ATL. Chemotherapy induced complete remission, but the human T-cell leukemia virus type 1 (HTLV-1) proviral load was detected in mononuclear cells of her peripheral blood. The patient received UCBT with a conditioning regimen consisting of total body irradiation, cytarabine, and cyclophosphamide. She remains in remission 30 months after UCBT and the HTLV-1 proviral load has fallen to undetectable levels. This result suggests that UCBT should be a therapeutic option for ATL patients who do not have suitable donors and those who urgently require treatment.
本研究报告了首例有充分文献记录的经非亲属脐血移植（UCBT）成功治疗的成人T细胞白血病（ATL）病例。一名49岁女性被诊断为急性型ATL。化疗诱导完全缓解，但在其外周血单个核细胞中检测到1型人类T细胞白血病病毒（HTLV-1）前病毒载量。该患者接受了由全身照射、阿糖胞苷和环磷酰胺组成的预处理方案的UCBT。脐血移植后30个月她仍处于缓解状态，且HTLV-1前病毒载量已降至检测不到的水平。这一结果表明，对于没有合适供体以及急需治疗的ATL患者，UCBT应是一种治疗选择。
