利用聚合酶链反应衍生探针将人丁酰胆碱酯酶基因定位至3号染色体3q26.1-q26.2区域的研究
Refinement of the localization of human butyrylcholinesterase to chromosome 3q26.1-q26.2 using a PCR-derived probe.
作者信息
Gaughan G, Park H, Priddle J, Craig I, Craig S
机构信息
Biochemistry Department, University of Oxford, United Kingdom.
出版信息
Genomics. 1991 Oct;11(2):455-8. doi: 10.1016/0888-7543(91)90155-8.
PMID:1769658
Abstract
The gene for butyrylcholinesterase (EC 3.1.1.8) has been previously localized to three sites in the human genome, at 3q21, 3q26, and 16q21. In situ hybridization using a PCR-derived probe including the active site region gives a single hybridization signal and refines the localization to 3q26.1-q26.2.
摘要
丁酰胆碱酯酶（EC 3.1.1.8）基因先前已定位到人类基因组中的三个位点，即3q21、3q26和16q21。使用包含活性位点区域的PCR衍生探针进行原位杂交，产生单一杂交信号，并将定位精确到3q26.1-q26.2。
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