Menon Rukmini, Stacy Mark
Duke University Medical Center, Durham, NC 27705, USA.
Expert Opin Pharmacother. 2007 Aug;8(12):1941-50. doi: 10.1517/14656566.8.12.1941.
Motor fluctuations, refractory to conventional medical management, are one of the most troubling aspects of Parkinson's disease. Apomorphine is a dopaminergic agent that has been known to the medical community for more than a century, but has only recently been developed to treat such motor fluctuations. In this article, the authors review the historical background, structure, mechanism of action, pharmacologic properties, clinical trials, indications and side effects, as well as avenues of further research, of apomorphine.
运动波动对传统药物治疗无效，是帕金森病最棘手的问题之一。阿扑吗啡是一种多巴胺能药物，医学界对其了解已有一个多世纪，但直到最近才被开发用于治疗此类运动波动。在本文中，作者回顾了阿扑吗啡的历史背景、结构、作用机制、药理特性、临床试验、适应症和副作用，以及进一步研究的方向。
