灼口综合征（BMS）：唾液流量及唾液化学成分分析与唾液蛋白质谱
Burning mouth syndrome (BMS): sialometric and sialochemical analysis and salivary protein profile.
作者信息
de Moura Sérgio Adriane Bezerra, de Sousa Jacira Maria Andrade, Lima Dilma Ferreira, Negreiros André Newton do Monte, Silva Fábio de Vasconcelos, da Costa Lino João
机构信息
Faculdade de Odontologia, Universidade Federal da Paraíba-João Pessoa, Brazil/Universidade Federal da Bahia, Salvador, Brazil.
出版信息
Gerodontology. 2007 Sep;24(3):173-6. doi: 10.1111/j.1741-2358.2007.00158.x.
OBJECTIVE
The aim of the present study was to analyse the characteristics of salivary production and its composition in individuals with burning mouth syndrome (BMS).
STUDY DESIGN
Salivary flow rate, concentrations of potassium, iron, chloride, thiocyanate, magnesium, calcium, phosphorus, glucose, total protein and urea, as well as the expression profile of salivary proteins were analysed by SDS-PAGE.
RESULTS
The mean salivary flow rate among control patients was lower than that of BMS patients. Chloride, phosphorus and potassium levels were elevated in patients with BMS (p = 0.041, 0.001 and 0.034, respectively). Total salivary protein concentration was reduced in individuals with BMS (p = 0.223). Analysis of the expression of salivary proteins by Coomassie blue SDS-PAGE revealed a lower expression of low molecular weight proteins in individuals with BMS compared to healthy controls.
CONCLUSIONS
These results indicate that the identification and characterisation of low molecular weight salivary proteins in BMS may be important in understanding BMS pathogenesis, thus contributing to its diagnosis and treatment.
目的
本研究旨在分析灼口综合征（BMS）患者的唾液分泌特征及其成分。
研究设计
通过SDS-PAGE分析唾液流速、钾、铁、氯、硫氰酸盐、镁、钙、磷、葡萄糖、总蛋白和尿素的浓度，以及唾液蛋白的表达谱。
结果
对照组患者的平均唾液流速低于BMS患者。BMS患者的氯、磷和钾水平升高（分别为p = 0.041、0.001和0.034）。BMS患者的唾液总蛋白浓度降低（p = 0.223）。考马斯亮蓝SDS-PAGE分析唾液蛋白表达显示，与健康对照相比，BMS患者中低分子量蛋白的表达较低。
结论
这些结果表明，鉴定和表征BMS中的低分子量唾液蛋白可能对理解BMS发病机制很重要，从而有助于其诊断和治疗。
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