Kommedal Oyvind, Nystad Tone Wikene, Bølstad Bente, Digranes Asbjørn
Department of Microbiology and Immunology, The Gade Institute, Haukeland University Hospital, Bergen, Norway.
APMIS. 2007 Aug;115(8):956-61. doi: 10.1111/j.1600-0463.2007.apm_537.x.
In the present study the susceptibility of 200 blood culture isolates of anaerobic bacteria to benzylpenicillin, clindamycin, metronidazole, imipenem and piperacillin-tazobactam was examined. Metronidazole, imipenem, and piperacillin-tazobactam showed the highest activity, with 98.5% of the isolates being fully susceptible to either agent. A high rate of reduced susceptibility to clindamycin among both Bacteroides spp. (37%) and Clostridium spp. (28%) was found. Almost all Bacteroides isolates were resistant to penicillin, and only 60% of Prevotella spp. were susceptible to this agent. The antibiotic susceptibility of anaerobic bacteria in Norway should be surveyed regularly.
在本研究中，检测了200株厌氧细菌血培养分离株对苄青霉素、克林霉素、甲硝唑、亚胺培南和哌拉西林-他唑巴坦的敏感性。甲硝唑、亚胺培南和哌拉西林-他唑巴坦显示出最高活性，98.5%的分离株对这两种药物中的任何一种完全敏感。在拟杆菌属（37%）和梭菌属（28%）中均发现对克林霉素敏感性降低的比例较高。几乎所有拟杆菌分离株对青霉素耐药，仅60%的普雷沃菌属对该药物敏感。挪威应定期调查厌氧细菌的抗生素敏感性。
