Stock Ann M
Structure. 2007 Aug;15(8):887-8. doi: 10.1016/j.str.2007.07.003.
Characterization of an activated diguanylate cyclase reported in this issue of Structure by Wassmann et al. (2007) reveals how phosphorylation promotes dimerization necessary for synthesis of the second messenger c-di-GMP, establishes the catalytic mechanism, and identifies a widely conserved mode of product inhibition.
瓦斯曼等人(2007年)在本期《结构》杂志上报道的一种活化二鸟苷酸环化酶的特性揭示了磷酸化如何促进第二信使环二鸟苷酸(c-di-GMP)合成所需的二聚化,确立了催化机制,并确定了一种广泛保守的产物抑制模式。