磷脂酰肌醇-4,5-二磷酸——万能钥匙。
PIP2--the master key.
作者信息
Guy-David Liora, Reuveny Eitan
机构信息
Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel.
出版信息
Neuron. 2007 Aug 16;55(4):537-8. doi: 10.1016/j.neuron.2007.08.001.
The function of inwardly rectifying K+ (Kir) channels is highly diverse and therefore is tightly regulated by various environmental factors. In their article in this issue of Neuron, Rapedius et al. recognize a conserved structural mechanism for Kir channels gating by both pH and PIP2. In light of these findings and accumulated knowledge, PIP2 is suggested to have a common coregulatory role in the gating of Kir channels by all their soluble modulators.
内向整流钾离子（Kir）通道的功能高度多样，因此受到各种环境因素的严格调控。在本期《神经元》杂志上发表的文章中，拉佩迪乌斯等人发现了一种由pH值和磷脂酰肌醇-4,5-二磷酸（PIP2）共同调控Kir通道门控的保守结构机制。根据这些发现以及积累的知识，有人提出PIP2在所有可溶性调节剂对Kir通道的门控过程中具有共同的协同调节作用。
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