Colla Michael, Ende Gabriele, Alm Barbara, Deuschle Michael, Heuser Isabella, Kronenberg Golo
Department of Psychiatry, Charité-University Medicine Berlin, Campus Benjamin Franklin, Eschenallee 3, 14050 Berlin, Germany.
J Psychiatr Res. 2008 Jun;42(7):587-95. doi: 10.1016/j.jpsychires.2007.06.006. Epub 2007 Aug 14.
The anterior cingulate cortex (ACC) plays a major role in modulating executive control of attention. Here, 15 medication-nai ve patients with attention deficit/hyperactivity disorder (ADHD) and 10 carefully matched healthy controls were studied with 2D (1)H-magnetic resonance spectroscopic imaging (MRSI) of the ACC [Brodmann areas 24b'-c' and 32']. Attentional skills were assessed using the identical pairs version of the continuous performance task (CPT-IP). Analysis of regional brain spectra revealed a significantly increased signal of choline-containing compounds (Ch) in the ACC of ADHD patients (p<0.05). Across and within groups, the Ch signal showed high correlations with slowed hit reaction times on the CPT-IP. No group differences in N-acetyl-aspartate (NAA) and creatine (tCr) were detectable. The combination of performance deficits and elevated Ch levels in the ACC supports the hypothesis that subtle structural abnormalities underlie the functional alterations in ACC activation previously observed in ADHD patients.
前扣带回皮质（ACC）在调节注意力的执行控制方面发挥着主要作用。在此，对15名未服用过药物的注意力缺陷多动障碍（ADHD）患者和10名精心匹配的健康对照者进行了ACC[布罗德曼区24b'-c'和32']的二维（1）H磁共振波谱成像（MRSI）研究。使用连续性能任务的相同配对版本（CPT-IP）评估注意力技能。对局部脑波谱的分析显示，ADHD患者ACC中含胆碱化合物（Ch）的信号显著增加（p<0.05）。在组间和组内，Ch信号与CPT-IP上减慢的击中反应时间高度相关。未检测到N-乙酰天门冬氨酸（NAA）和肌酸（tCr）的组间差异。ACC中表现缺陷和Ch水平升高的组合支持了这样一种假设，即细微的结构异常是先前在ADHD患者中观察到的ACC激活功能改变的基础。
