Filion Edith, Taussky Daniel, Bahary Jean-Paul, Maugard Christine M
Département de Radio-Oncologie, Centre Hospitalier Université de Montréal, Montréal, Québec, Canada.
J Urol. 2007 Oct;178(4 Pt 1):1265-9; discussion 1270. doi: 10.1016/j.juro.2007.05.131. Epub 2007 Aug 14.
Prostate cancer is the second cause of cancer related death in North American men. We investigated the frequency of familial clustering in a French-Canadian population of prostate cancer cases.
Between October 2004 and September 2005, 179 consecutively seen patients with localized prostate cancer identified each of their parents as being of French-Canadian descent. They were asked for their family history of cancer in first-degree relatives, age at diagnosis, whether affected relatives were alive, age and markers of tumor aggressiveness, including prostate specific antigen, Gleason and disease stage. ANOVA was used to compare the distribution of quantitative factors according to qualitative factors identified in our population. Differences between qualitative factors were assessed by the Fisher exact test. All p values were 2-sided.
Mean age at diagnosis was 67 years. A total of 45 French-Canadian patients (25.1%) had at least 1 first-degree relative with prostate cancer, including 34 (19%) with 1 first-degree relative, 9 with a father-son pair, 25 with a brother-brother pair and 11 (6.1%) with at least 2 first-degree relatives. In our series the frequency of familial clustering defined by at least 1 relative with prostate cancer was high. We found a higher percent of French-Canadian men with at least 1 first-degree relative with prostate cancer than what was previously reported for an unselected population in Canada (25.1% vs 14.7%, p <0.0001).
Those preliminary results open a new perspective to a better understanding of familial prostate cancer in the Province of Quebec.
前列腺癌是北美男性癌症相关死亡的第二大原因。我们调查了法裔加拿大前列腺癌患者群体中家族聚集的频率。
在2004年10月至2005年9月期间，179例连续就诊的局限性前列腺癌患者确认其父母均为法裔加拿大血统。他们被询问了一级亲属的癌症家族史、诊断时的年龄、受影响的亲属是否在世、年龄以及肿瘤侵袭性标志物，包括前列腺特异性抗原、Gleason评分和疾病分期。方差分析用于比较根据我们人群中确定的定性因素的定量因素分布。定性因素之间的差异通过Fisher精确检验进行评估。所有p值均为双侧。
诊断时的平均年龄为67岁。共有45例法裔加拿大患者（25.1%）至少有1名患前列腺癌的一级亲属，其中34例（19%）有1名一级亲属，9例为父子对，25例为兄弟对，11例（6.1%）至少有2名一级亲属。在我们的系列研究中，由至少1名患前列腺癌的亲属定义的家族聚集频率很高。我们发现，至少有1名患前列腺癌的一级亲属的法裔加拿大男性比例高于此前加拿大未经过筛选人群的报告比例（25.1%对14.7%，p<0.0001）。
这些初步结果为更好地理解魁北克省的家族性前列腺癌开辟了新的视角。
