Hanauer Stephen B
Department of Medicine and Clinical Pharmacology, University of Chicago Hospital, 5841 S. Maryland Ave., MC 4076, Chicago, IL 60637, USA.
Gut. 2007 Sep;56(9):1181-3. doi: 10.1136/gut.2006.115980.
Since the introduction of infliximab to treat Crohn's disease, combination therapy with immunosuppressants has reduced immunogenicity, without impacting efficacy. The availability of novel anti-TNF agents and potential combined toxicities question the risk/benefit of combination therapies.
自从英夫利昔单抗被用于治疗克罗恩病以来,与免疫抑制剂的联合疗法降低了免疫原性,且不影响疗效。新型抗TNF药物的出现以及潜在的联合毒性引发了对联合疗法风险/获益的质疑。