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类风湿关节炎中对抗肿瘤坏死因子药物的差异耐药性

Differential drug resistance to anti-tumour necrosis factor agents in rheumatoid arthritis.

作者信息

Sidiropoulos P I, Boumpas D T

出版信息

Ann Rheum Dis. 2006 Jun;65(6):701-3. doi: 10.1136/ard.2005.049890.

DOI:10.1136/ard.2005.049890
PMID:16699049
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1798160/
Abstract

A significant number of patients receiving infliximab require dosing adjustments while some patients may indeed develop drug resistance

摘要

相当数量接受英夫利昔单抗治疗的患者需要调整剂量，而一些患者可能确实会产生耐药性。

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本文引用的文献

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The LUNDEX, a new index of drug efficacy in clinical practice: results of a five-year observational study of treatment with infliximab and etanercept among rheumatoid arthritis patients in southern Sweden.LUNDEX，一种临床实践中药物疗效的新指标：瑞典南部类风湿关节炎患者使用英夫利昔单抗和依那西普治疗的五年观察性研究结果
Arthritis Rheum. 2006 Feb;54(2):600-6. doi: 10.1002/art.21570.
2
Acquired resistance to chloroquine in human CEM T cells is mediated by multidrug resistance-associated protein 1 and provokes high levels of cross-resistance to glucocorticoids.人CEM T细胞对氯喹的获得性耐药由多药耐药相关蛋白1介导，并引发对糖皮质激素的高水平交叉耐药。
Arthritis Rheum. 2006 Feb;54(2):557-68. doi: 10.1002/art.21569.
3
Anti-infliximab antibodies in patients with rheumatoid arthritis who require higher doses of infliximab to achieve or maintain a clinical response.类风湿关节炎患者中需要更高剂量英夫利昔单抗以实现或维持临床缓解的抗英夫利昔单抗抗体。
J Rheumatol. 2006 Jan;33(1):31-6.
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The effectiveness of anti-tumor necrosis factor therapy in preventing progressive radiographic joint damage in rheumatoid arthritis: a population-based study.抗肿瘤坏死因子疗法在预防类风湿关节炎患者影像学关节损害进展方面的有效性：一项基于人群的研究。
Arthritis Rheum. 2006 Jan;54(1):54-9. doi: 10.1002/art.21491.
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Evidence for differential acquired drug resistance to anti-tumour necrosis factor agents in rheumatoid arthritis.类风湿关节炎中对抗肿瘤坏死因子药物获得性耐药差异的证据。
Ann Rheum Dis. 2006 Jun;65(6):746-52. doi: 10.1136/ard.2005.045062. Epub 2005 Dec 8.
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Infliximab dose and clinical status: results of 2 studies in 1642 patients with rheumatoid arthritis.英夫利昔单抗剂量与临床状况：针对1642例类风湿关节炎患者的两项研究结果
J Rheumatol. 2004 Aug;31(8):1538-45.