Patwardhan Meenal B, Samsa Gregory P, Matchar David B, Haley William E
Duke Center for Clinical Health Policy Research, 2200 W. Main Street, Suite 220, Durham, NC 27705, USA.
Clin J Am Soc Nephrol. 2007 Mar;2(2):277-83. doi: 10.2215/CJN.02600706. Epub 2007 Jan 3.
Chronic kidney disease (CKD) outcomes, including progression to end stage, is influenced by patient treatment and is known to be suboptimal. A commercial database was analyzed to assess practice patterns and conformance to clinical practice guidelines among nephrologists and non-nephrologists who care for patients with advanced CKD (estimated GFR [eGFR] < or = 30 ml/min per 1.73 m2). Data from 1933 adults with advanced CKD on the basis of prestipulated inclusion criteria were analyzed. Individuals were designated as in a nephrologist or non-nephrologist group depending on whether a nephrologist was involved in their care. With the use of published guidelines, conformance to 10 recommendations was assessed for all patients and separately for the nephrologist and non-nephrologist groups. The average eGFR of included individuals was 23.6 ml/min per 1.73 m2. A majority were female and older than 65 yr. Non-nephrologists treated approximately half of all patients and a greater number of women and patients who were older than 65 yr. Nephrologists treated patients with a lower eGFR, equal numbers of men and women, and an equal number of individuals younger and older than 65 yr. Nephrologist conformance to guidelines was systematically better than that of non-nephrologists. These analyses reveal that a large number of patients with advanced CKD are being treated solely by non-nephrologists and that nephrologists treat patients with more advanced disease. Management of advanced CKD is suboptimal for all patients but is particularly poor for patients who are treated solely by non-nephrologists.
慢性肾脏病(CKD)的预后,包括进展至终末期,受患者治疗情况的影响,且已知其治疗效果欠佳。对一个商业数据库进行了分析,以评估在照顾晚期CKD患者(估计肾小球滤过率[eGFR]≤30 ml/min/1.73 m²)的肾病专家和非肾病专家的诊疗模式及对临床实践指南的遵循情况。根据预先设定的纳入标准,对1933例晚期CKD成年患者的数据进行了分析。根据是否有肾病专家参与其治疗,将个体分为肾病专家组或非肾病专家组。参照已发表的指南,评估了所有患者以及肾病专家组和非肾病专家组分别对10项推荐意见的遵循情况。纳入个体的平均eGFR为23.6 ml/min/1.73 m²。大多数为女性,年龄超过65岁。非肾病专家治疗了约一半的患者,以及更多的女性患者和年龄超过65岁的患者。肾病专家治疗的患者eGFR较低,男女患者数量相等,65岁及以下和65岁以上的患者数量也相等。肾病专家对指南的遵循情况在系统性上优于非肾病专家。这些分析表明,大量晚期CKD患者仅由非肾病专家治疗,且肾病专家治疗的是病情更严重的患者。晚期CKD的管理对所有患者而言都欠佳,但对仅由非肾病专家治疗的患者而言尤其糟糕。