头孢匹罗在肺部感染潜在部位的渗透情况。

The penetration of cefpirome into the potential sites of pulmonary infection.

作者信息

Baldwin D R, Maxwell S R, Honeybourne D, Andrews J M, Ashby J P, Wise R

机构信息

Department of Thoracic Medicine, Dudley Road Hospital, Birmingham, UK.

出版信息

J Antimicrob Chemother. 1991 Jul;28(1):79-86. doi: 10.1093/jac/28.1.79.

DOI:10.1093/jac/28.1.79

PMID:1769946

Abstract

The concentrations of cefpirome, a new semi-synthetic cephalosporin, in the bronchial mucosa and serum were assessed after a single 1 g intravenous dose in 37 patients. Bronchoalveolar lavage allowed epithelial lining fluid (ELF) concentrations to be measured in eight subjects. The mean concentration for serum was 34.5 mg/L (S.E.M. 3.3), for bronchial mucosa 19.3 mg/kg (S.E.M. 1.9) and for ELF 7.2 mg/L (S.E.M. 1.1). The progressive reduction in cefpirome concentration in serum compared to that in bronchial mucosa and ELF is consistent with the permeability characteristics of beta-lactam antimicrobials and the barriers to movement of antimicrobial agents present in the lung.

摘要

在37例患者单次静脉注射1g新型半合成头孢菌素头孢匹罗后，对其在支气管黏膜和血清中的浓度进行了评估。通过支气管肺泡灌洗测定了8名受试者上皮衬液（ELF）中的浓度。血清的平均浓度为34.5mg/L（标准误3.3），支气管黏膜为19.3mg/kg（标准误1.9），ELF为7.2mg/L（标准误1.1）。与支气管黏膜和ELF相比，血清中头孢匹罗浓度的逐渐降低与β-内酰胺类抗菌药物的通透性特征以及肺部存在的抗菌药物移动屏障相一致。