Crowell James A, Steele Vernon E, Fay Judith R
Division of Cancer Prevention, National Cancer Institute, NIH, Executive Plaza North, Room 2117, 900 Rockville Pike, Bethesda, MD 20892, USA.
Mol Cancer Ther. 2007 Aug;6(8):2139-48. doi: 10.1158/1535-7163.MCT-07-0120.
The AKT protein kinase transduces signals from growth factors and oncogenes to downstream targets that control crucial elements in tumor development. The AKT pathway is one of the most frequently hyperactivated signaling pathways in human cancers. Available data are reviewed herein to support targeting the AKT kinase for cancer prevention. This review will present data to show that AKT is up-regulated in preneoplastic lesions across a broad range of target tissues, briefly describe drug development efforts in this area, and present evidence that down-regulation of AKT signaling may be a viable strategy to prevent cancer.
AKT蛋白激酶将来自生长因子和癌基因的信号转导至下游靶点，这些靶点控制着肿瘤发展中的关键要素。AKT信号通路是人类癌症中最常过度激活的信号通路之一。本文综述现有数据以支持将AKT激酶作为癌症预防的靶点。本综述将展示数据表明AKT在广泛的靶组织的癌前病变中上调，简要描述该领域的药物研发工作，并提供证据表明下调AKT信号可能是预防癌症的可行策略。
