内质网-线粒体通讯。有多特殊？
ER-mitochondria communication. How privileged?
作者信息
Franzini-Armstrong Clara
机构信息
Department of Cell and Developmental Biology, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
出版信息
Physiology (Bethesda). 2007 Aug;22:261-8. doi: 10.1152/physiol.00017.2007.
PMID:17699879
Abstract
Mitochondria have a low affinity for Ca(2+), but they take up these ions during normal cell activity because they are in close proximity to the sites of calcium entry into the cell and of internal Ca(2+) release. This gives mitochondria privileged access to cytoplasmic Ca(2+) without requiring a direct communication with the endoplasmic reticulum.
摘要
线粒体对钙离子（Ca²⁺）的亲和力较低，但在正常细胞活动期间它们会摄取这些离子，因为它们紧邻钙离子进入细胞的位点以及细胞内钙离子（Ca²⁺）释放的位点。这使得线粒体能够优先获取细胞质中的钙离子（Ca²⁺），而无需与内质网进行直接通信。
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