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注意力缺陷多动障碍儿童长期学业成果的影响因素:使用兴奋剂药物治疗会有不同吗?一项基于人群研究的结果

Modifiers of long-term school outcomes for children with attention-deficit/hyperactivity disorder: does treatment with stimulant medication make a difference? Results from a population-based study.

作者信息

Barbaresi William J, Katusic Slavica K, Colligan Robert C, Weaver Amy L, Jacobsen Steven J

机构信息

Department of Pediatric and Adolescent Medicine, Division of Developmental and Behavioral Pediatrics, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.

出版信息

J Dev Behav Pediatr. 2007 Aug;28(4):274-87. doi: 10.1097/DBP.0b013e3180cabc28.

Abstract

OBJECTIVE

The purpose of this study was to describe the significance of potential modifiers of long-term school outcomes among children with attention-deficit/hyperactivity disorder (AD/HD), including treatment with stimulant medication.

METHODS

Subjects included 370 children with research-identified AD/HD from a 1976-1982 population-based birth cohort (N = 5718). In a companion study, the complete school record for each subject was reviewed to obtain information on reading achievement, absenteeism, grade retention, and school dropout. Data on type of stimulant, dose, age at initiation of treatment, and start/stop dates were collected from medical and school records, available for all subjects.

RESULTS

Treatment with stimulants was associated with decreased rates of absenteeism; longer duration of treatment was also associated with decreased absenteeism rates. There was a modest positive correlation (r = .15, p = .012) between average daily stimulant dose and last reading score. Cases treated with stimulants were 1.8 times less likely to subsequently be retained a grade (95% confidence interval: 1.01-3.2; p = .047). The proportion of school dropout was similar between treated and not treated cases (22.2% vs 25.8%, p = .54). Other potential modifiers of school outcomes (sociodemographic risk factors, presence of comorbid learning or psychiatric disorders, and receipt of special educational services) were also examined and found to be associated with poorer outcomes.

CONCLUSIONS

In this birth cohort, stimulant treatment of children with AD/HD was associated with improved reading achievement, decreased school absenteeism, and decreased grade retention. This study provides support for efforts to ensure that children with AD/HD receive appropriate long-term medical treatment.

摘要

目的

本研究旨在描述注意力缺陷多动障碍(AD/HD)患儿长期学业成绩潜在调节因素的意义,包括使用兴奋剂药物治疗的影响。

方法

研究对象包括1976 - 1982年基于人群的出生队列中370名经研究确定患有AD/HD的儿童(队列总数N = 5718)。在一项配套研究中,查阅了每个研究对象的完整学校记录,以获取阅读成绩、缺勤情况、留级情况和辍学情况的信息。从医疗和学校记录中收集了所有研究对象的兴奋剂类型、剂量、开始治疗的年龄以及开始/停止日期的数据。

结果

使用兴奋剂治疗与缺勤率降低相关;治疗时间越长,缺勤率也越低。每日平均兴奋剂剂量与最后阅读成绩之间存在适度正相关(r = 0.15,p = 0.012)。接受兴奋剂治疗的患儿随后留级的可能性降低1.8倍(95%置信区间:1.01 - 3.2;p = 0.047)。治疗组和未治疗组的辍学比例相似(22.2%对25.8%,p = 0.54)。还研究了其他学业成绩的潜在调节因素(社会人口统计学风险因素、合并学习或精神疾病的存在以及接受特殊教育服务情况),发现这些因素与较差的学业成绩相关。

结论

在这个出生队列中,对AD/HD患儿进行兴奋剂治疗与阅读成绩提高、学校缺勤率降低和留级率降低相关。本研究为确保AD/HD患儿接受适当的长期药物治疗的努力提供了支持。

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