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视神经修复:新视角

Optic nerve restoration: new perspectives.

作者信息

Bull Natalie D, Martin Keith R

机构信息

Centre for Brain Repair, Cambridge University, UK.

出版信息

J Glaucoma. 2007 Aug;16(5):506-11. doi: 10.1097/IJG.0b013e3180391a18.

DOI:10.1097/IJG.0b013e3180391a18
PMID:17700293
Abstract

Neural regeneration and repair in the central nervous system are currently hot topics in neuroscience. For many years there has been a hope that neurodegenerative diseases which are resistant to current therapies may be treated by the selective replacement of cells. Yet it is only recently that we have started to acquire the knowledge, tools, and techniques that may translate such optimism into new therapies. In this article, we will consider the potential to restore function to the damaged optic nerve. We will consider the technical issues involved and suggest a strategy for research progress.

摘要

中枢神经系统中的神经再生与修复是当前神经科学领域的热门话题。多年来,人们一直希望那些对现有疗法有抗性的神经退行性疾病或许可以通过选择性细胞替代来治疗。然而,直到最近我们才开始获得可能将这种乐观想法转化为新疗法的知识、工具和技术。在本文中,我们将探讨恢复受损视神经功能的潜力。我们将考虑其中涉及的技术问题,并提出研究进展的策略。

相似文献

1
Optic nerve restoration: new perspectives.视神经修复:新视角
J Glaucoma. 2007 Aug;16(5):506-11. doi: 10.1097/IJG.0b013e3180391a18.
2
[Anatomy, physiology, and functional exploration of the optic nerve].[视神经的解剖学、生理学及功能探索]
Rev Prat. 2001 Dec 15;51(20):2185-92.
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[Perspectives for the clinical application of the results of current neuromorphological studies of the optical nerve lesions and atrophies].[当前视神经病变与萎缩神经形态学研究结果的临床应用前景]
Morfologiia. 2003;123(3):94-102.
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Stem cells to replace the optic nerve.用于替换视神经的干细胞。
Eye (Lond). 2004 Nov;18(11):1085-8. doi: 10.1038/sj.eye.6701577.
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Gene therapy and transplantation in CNS repair: the visual system.中枢神经系统修复中的基因治疗与移植:视觉系统
Prog Retin Eye Res. 2006 Sep;25(5):449-89. doi: 10.1016/j.preteyeres.2006.07.002. Epub 2006 Sep 11.
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Potential treatment modalities for glaucomatous neuropathy: neuroprotection and neuroregeneration.
J Glaucoma. 1996 Dec;5(6):427-32.
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Neuroprotection: the next breakthrough in glaucoma? Proceedings of the Third Annual Optic Nerve Rescue and Restoration Think Tank.神经保护:青光眼的下一个突破?第三届视神经抢救与修复智囊团会议论文集
J Glaucoma. 1997 Aug;6(4):263-6.
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Engrafted chicken neural tube-derived stem cells support the innate propensity for axonal regeneration within the rat optic nerve.移植的鸡神经管源性干细胞支持大鼠视神经轴突再生的先天倾向。
Invest Ophthalmol Vis Sci. 2008 Aug;49(8):3513-24. doi: 10.1167/iovs.07-1473. Epub 2008 Apr 11.
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Does CNTF mediate the effect of intraocular inflammation on optic nerve regeneration?睫状神经营养因子是否介导眼内炎症对视神经再生的影响?
Brain. 2008 Jun;131(Pt 6):e96; author reply e97. doi: 10.1093/brain/awn027. Epub 2008 Feb 19.
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Molecular and cell-based approaches for neuroprotection in glaucoma.青光眼神经保护的分子与细胞疗法
Optom Vis Sci. 2008 Jun;85(6):417-24. doi: 10.1097/OPX.0b013e31817841f7.

引用本文的文献

1
Stem cell therapy for glaucoma: possibilities and practicalities.青光眼的干细胞治疗:可能性与实际应用
Expert Rev Ophthalmol. 2011 Apr 1;6(2):165-174. doi: 10.1586/eop.11.3.
2
Stem cell sources and therapeutic approaches for central nervous system and neural retinal disorders.中枢神经系统和神经视网膜疾病的干细胞来源及治疗方法。
Neurosurg Focus. 2008;24(3-4):E11. doi: 10.3171/FOC/2008/24/3-4/E10.