Togawa M, Kikkawa R, Haneda M, Koya D, Horide N, Kajiwara N, Shigeta Y
Third Department of Medicine, Shiga University of Medical Science, Japan.
J Diabet Complications. 1991 Apr-Sep;5(2-3):184-5. doi: 10.1016/0891-6632(91)90067-y.
Cultured mesangial cells possess a large number of receptors specific to IGF-I with a small number of insulin receptors. Physiological concentrations of IGF-I increased the uptakes of aminoisobutyric acid and 2-deoxyglucose in mesangial cells, while insulin exhibited similar effects only with unphysiologically high concentration. These findings suggest that, in cultured mesangial cells, IGF-I may regulate cellular metabolic functions such as glucose and amino acid uptakes through its own receptors rather than insulin receptors.
培养的系膜细胞拥有大量胰岛素样生长因子-I（IGF-I）特异性受体，仅有少量胰岛素受体。生理浓度的IGF-I可增加系膜细胞中氨基异丁酸和2-脱氧葡萄糖的摄取，而胰岛素仅在非生理高浓度时才表现出类似作用。这些发现表明，在培养的系膜细胞中，IGF-I可能通过自身受体而非胰岛素受体调节细胞代谢功能，如葡萄糖和氨基酸摄取。
