Prockop D J
Tulane Center for Gene Therapy, Tulane University Health Sciences Center, New Orleans, Louisiana, USA.
Clin Pharmacol Ther. 2007 Sep;82(3):241-3. doi: 10.1038/sj.clpt.6100313.
There has recently been an explosion of interest in adult stem/progenitor cells that have the potential to repair tissues, with over 3,000 citations to publications (PubMed) and numerous announcements of clinical trials in which the cells are used to treat individuals with a broad range of diseases. At the same time, the data present a paradox-the cells originally attracted attention because of their stem-cell-like properties, but the cells frequently repair injured tissues without much evidence of either engraftment or differentiation.
最近，人们对具有修复组织潜力的成体干细胞/祖细胞的兴趣激增，相关出版物（PubMed）被引用超过3000次，并且有许多关于临床试验的报道，其中这些细胞被用于治疗患有多种疾病的个体。与此同时，数据呈现出一个悖论——这些细胞最初因其类似干细胞的特性而受到关注，但它们在修复受损组织时，却常常没有太多植入或分化的证据。
