Okor R S
Department of Pharmaceutics, College of Medical Sciences, University of Benin, Nigeria.
J Clin Pharm Ther. 1991 Dec;16(6):463-5. doi: 10.1111/j.1365-2710.1991.tb00336.x.
The effectiveness of an antihistamine, chlorpheniramine, in suppressing chloroquine-related pruritus has been investigated in 38 patients, employing two modes of therapy. In the first treatment mode, chloroquine and chlorpheniramine were given concomitantly to the patient, and in the second treatment mode, chlorpheniramine was given 3 h after chloroquine ingestion. The extent of suppression of the pruritus with the first treatment mode was 40% but with the second mode it was 70%. The onset of itching was always delayed usually by 6-10 h. Bringing the time of antihistamine therapy closer to the onset for the reaction therefore, increased the extent to which pruritus was suppressed.
已采用两种治疗方式，对38例患者研究了抗组胺药氯苯那敏抑制氯喹相关瘙痒的效果。在第一种治疗方式中，氯喹和氯苯那敏同时给予患者，在第二种治疗方式中，氯苯那敏在摄入氯喹3小时后给予。第一种治疗方式对瘙痒的抑制程度为40%，而第二种方式为70%。瘙痒发作总是延迟，通常延迟6 - 10小时。因此，使抗组胺药治疗时间更接近反应发作时间，可增加瘙痒的抑制程度。
