Kim Chulhong, Wang Lihong V
Department of Biomedical Engineering, Optical Imaging Laboratory, Washington University in St. Louis, One Brookings Drive, St. Louis, MO 63130, USA.
Opt Lett. 2007 Aug 15;32(16):2285-7. doi: 10.1364/ol.32.002285.
We used multiple optical wavelengths to study ultrasound-modulated optical tomography (UOT) in tissue phantoms. By using intense acoustic bursts and a CCD camera-based speckle contrast detection technique, we observed variations of the ultrasound-modulated signal at various optical absorptions. The experimental variations were found to be highly correlated with predictions from Monte Carlo simulations. By irradiating the sample at two optical wavelengths, we quantitatively estimated the total concentration and the concentration ratio of double dyes in objects embedded in tissue phantoms. The results suggest that UOT can potentially provide noninvasive functional imaging of the total concentration and oxygen saturation of hemoglobin in biological tissue.
我们使用多个光学波长来研究组织模型中的超声调制光学层析成像（UOT）。通过使用高强度声脉冲串和基于电荷耦合器件（CCD）相机的散斑对比度检测技术，我们观察了在各种光吸收情况下超声调制信号的变化。发现实验变化与蒙特卡罗模拟的预测高度相关。通过在两个光学波长下照射样品，我们定量估计了嵌入组织模型中的物体中双染料的总浓度和浓度比。结果表明，UOT有可能提供生物组织中血红蛋白总浓度和氧饱和度的无创功能成像。
