Maghbooli Zhila, Hossein-Nezhad Arash, Nikoo Mohsen Khoshniat, Shafei Ali R, Rahmani Mazaher, Larijani Bagher
Endocrinology and Metabolism Research Center, Medical Sciences, University of Tehran, Tehran, Iran.
J Matern Fetal Neonatal Med. 2007 Sep;20(9):639-43. doi: 10.1080/14767050701483470.
The contribution of maternal skeletal calcium metabolism in pregnancy is evidenced in changes in the markers of bone formation and bone resorption. Changes in maternal bone markers could affect fetal bone mineralization. The aim of this study was to determine the association between maternal and cord blood bone markers.
Five hundred and fifty-two pregnant women were recruited from Tehran University educating hospitals in the winter of 2002. Maternal and cord blood samples were taken at delivery. The serum was assayed for osteocalcin and crosslaps, calcium, and parathyroid hormone.
There was significant correlation between maternal and cord blood serum osteocalcin and crosslaps levels, and the mean cord blood levels of osteocalcin and crosslaps were significantly higher at about 1.59- and 1.62-fold maternal levels, respectively. Serum calcium levels strongly correlated with osteocalcin and crosslaps in mothers (r = 0.21, p = 0.001 and r = 0.25, p = 0.001, respectively).
Skeletal calcium release may play a major role in calcium homeostasis during pregnancy. Because of this, calcium supplements could have an important role in pregnant women in decreasing the risk of subsequent complications such as osteoporosis.
孕期母体骨骼钙代谢的作用可通过骨形成和骨吸收标志物的变化得以证明。母体骨标志物的变化可能会影响胎儿的骨矿化。本研究的目的是确定母体和脐带血骨标志物之间的关联。
2002年冬季，从德黑兰大学教学医院招募了552名孕妇。在分娩时采集母体和脐带血样本。检测血清中的骨钙素、交联羧基末端肽、钙和甲状旁腺激素。
母体和脐带血血清骨钙素及交联羧基末端肽水平之间存在显著相关性，脐带血骨钙素和交联羧基末端肽的平均水平分别显著高于母体水平约1.59倍和1.62倍。母亲血清钙水平与骨钙素及交联羧基末端肽密切相关（r分别为0.21，p = 0.001和r = 0.25，p = 0.001）。
骨骼钙释放可能在孕期钙稳态中起主要作用。因此，补钙可能对孕妇降低后续骨质疏松等并发症风险具有重要作用。
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