痕迹性眨眼条件反射习得后大鼠CA1锥体神经元的神经元兴奋性增强并非由于M电流的改变。
Enhanced neuronal excitability in rat CA1 pyramidal neurons following trace eyeblink conditioning acquisition is not due to alterations in I M.
作者信息
Kuo Amy G, Lee Grace, McKay Bridget M, Disterhoft John F
机构信息
Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
出版信息
Neurobiol Learn Mem. 2008 Feb;89(2):125-33. doi: 10.1016/j.nlm.2007.07.002. Epub 2007 Aug 20.
Previous work done by our laboratory has demonstrated a reduction of the post-burst afterhyperpolarization (AHP) and accommodation following trace eyeblink conditioning in rabbit CA1 pyramidal neurons. Our laboratory has also demonstrated a reduction in the AHP in rat CA1 pyramidal neurons following spatial learning. In the current study we have extended our findings in rabbits by showing a reduction in both the AHP and accommodation in F344 X BN rat CA1 pyramidal neurons following acquisition of trace eyeblink conditioning. A component current of the AHP, I(M), was evaluated with a specific blocker of this current, and showed no apparent contribution to the learning-related increase in neuronal excitability. Rather, a reduction in an isoproterenol-sensitive component of the AHP, presumably sI(AHP), was observed to underlie the learning-specific change.
我们实验室之前的研究表明，家兔CA1锥体神经元在痕迹性眨眼条件反射后，爆发后超极化（AHP）和适应性降低。我们实验室还证明，大鼠CA1锥体神经元在空间学习后AHP降低。在本研究中，我们扩展了在兔子身上的发现，表明F344×BN大鼠CA1锥体神经元在获得痕迹性眨眼条件反射后，AHP和适应性均降低。使用该电流的特异性阻滞剂评估了AHP的一个成分电流I(M)，结果显示它对学习相关的神经元兴奋性增加没有明显贡献。相反，观察到AHP中异丙肾上腺素敏感成分（可能是sI(AHP)）的降低是学习特异性变化的基础。
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