Trendelenburg Marten
Internal Medicine B and, Clinicil Immunology lab, University Hospital Basel, Basel, Switzerland.
Swiss Med Wkly. 2007 Jul 28;137(29-30):413-7. doi: 10.4414/smw.2007.11792.
The complement system is an important part of the innate immune system with pro-inflammatory and regulatory functions. Although many experimental studies have demonstrated that complement inhibition might be advantageous in a number of different human diseases, complement inhibition is still not part of the clinical treatment routine. With blocking antibodies against complement C5 a new generation of therapeutic complement inhibitors has now been investigated in some human diseases. This review gives an overview on the new complement inhibitors and the results obtained in clinical studies thus far.
补体系统是固有免疫系统的重要组成部分，具有促炎和调节功能。尽管许多实验研究表明，补体抑制在多种不同的人类疾病中可能具有优势，但补体抑制仍未成为临床治疗常规的一部分。借助针对补体C5的阻断抗体，新一代治疗性补体抑制剂现已在一些人类疾病中进行了研究。本综述概述了新型补体抑制剂以及迄今为止在临床研究中获得的结果。
